As shown in Fig. 6a, children with asthma exacerbation had significantly lower level of miR-29c in monocytes compared to controls (0.48 ± 0.44 vs. 1.00 ± 0.63, relative expression) and higher level of plasma B7-H3 (20,594 ± 6706 vs. 14,180 ± 4920 pg/ml) shown in Fig. 6b. The gene discussed is CD276; the disease is asthma.