C9orf72 and amyotrophic lateral sclerosis: Therefore, the aim of the present study was to generate and characterize novel antibodies against C9orf72 with the goal to investigate the subcellular distribution and function of C9orf72 in the CNS and to test for haploinsufficiency on the protein level in postmortem brain tissue of ALS, ALS/FTD and FTD cases with C9orf72 repeat expansions.