PWRN2 and polycystic ovary syndrome: By comparing the potential target genes of miR-92b-3p and miR-365b-5p with the PWRN2-regulated mRNAs identified by KGN/shPWRN2 microarray, we found 12 mRNAs, including UPF2, VSIG10, CCDC144A, LRRC1, ZNF654, FHL2, NOS1AP, TMEM120B, GPI, CCDC6, RCAN3 and AMOTL1. Thus, a credible PWRN2-miRNA-mRNA ceRNA network was constructed using the combined analyses of the three microarrays (lncRNA+mRNA microarray in PCOS, miRNA microarray in PCOS and lncRNA+mRNA microarray in KGN/shPWRN2; Figs. 3A, B).