Low SHBG levels have been recognized to generally raise cardiometabolic risk in the TARF[44] as well as in other studies.[45] Although we have been unable to find a report on elevated SHBG as a risk factor, in an as TARF study SHBG, protecting against “hypertriglyceridemic waist” phenotype in women, elevated SHBG paradoxically conferred marked CHD risk.[46] This may be attributed to proinflammatory conversion of the SHBG when aggregated to serum apoB, an oxidatively damaged protein. This evidence concerns the gene SHBG and coronary artery disorder.