Cytokines will elevate TGF-β, and induce glomerular sclerosis and tubular interstitial fibrosis, which finally leads to DN.[16,17] In vitro experiments suggest that cytokines related to vascular injury and angiogenesis including fibrocyte growth factor, TGF-β and AngII can reduce OIF expression.[18] The activation of the AngII system is a major cause of renal hypertension supporting the finding of this research where SBP increased as OIF decreased with the deterioration of DN. This evidence concerns the gene TGFB1 and liver dysplastic nodule.