However, withdrawal of ACE-inhibitor is not always effective.[6] ACE inhibitor caused angioedema tends to be persistent, considering that the average time from edema onset to full resolution takes about 30 hours, even though it can last up to 5 days.[22,23] In our case, the complete resolution of angioedema presented after 13 days from the ramipril discontinuation. The gene discussed is ACE; the disease is angioedema.