Majority of angioedema cases were documented during first 30 days after ACE inhibitor exposure, although angioedema may develop at any time during the treatment course.[7,8] Delayed angioedema may be associated with poor recognition, because identifying the association between initiation of the ACE inhibitor therapy and symptoms is difficult.[9] We present a case of late-onset ACE inhibitor-induced angioedema, which resulted in cardiac arrest due to severe airway obstruction. This evidence concerns the gene ACE and angioedema.