The factors, which are associated with enhanced risk are age > 65 years, female gender, cough caused by ACE inhibitor, heart failure, black race, seasonal allergies, and history of smoking.[14–16] In our case, the patient presented with some risk factors for angioedema: female gender, > 65 years, cough caused by ACE inhibitor, and heart failure. The gene discussed is ACE; the disease is heart failure.