PIK3CA mutation is reportedly the most common genetic alteration in cervical cancers, followed by KRAS, EGFR, and then PTEN loss.[1] Thirteen to 36% of cervical cancers are reported to harbor PIK3CA mutations.[2]PIK3CA gene encodes p110α protein, the catalytic subunit of phosphoinositide 3-kinase (PI3K), and is known to be mutated or amplified in many kinds of human cancers. The gene discussed is PIK3CA; the disease is cervical cancer.