PIK3CA and cervical carcinoma: Likewise, PI3-kinase inhibitor LY294002 reportedly radiosensitized cervical cancer cell lines in vitro[11] and in vivo.[12] Moreover, Arjumand et al[13] recently examined in vitro whether mutated PIK3CA confers cervical cancer cells higher resistance to cisplatin and/or radiation, and whether this phenotype is reversed by inhibiting PI3K.