In multiple myeloma, miR‐221 could cause the drug resistance by abating the expression level of its target gene PUMA.8 In gallbladder cancer, miR‐130a mediated the oncogenic activity of HOTAIR because of HOTAIR harbours a miRNA‐130a binding site so HOTAIR could negatively regulated it.9 However, the dysregulation of miRNAs in HSCR10, 11 has not been stated thoroughly to date. Here, HOTAIR is linked to AL amyloidosis.