FHL1 and neoplasm: FHL1 has an elucidated vital role in the function of cell proliferation, differentiation and apoptosis44 and has been shown anomalous in various malignant tumours including breast, kidney, prostate45 and gastric cancers.46 On account of its important roles in the neoplasm, we were eager to investigate the underlying mechanism of FHL1 in HSCR when both the mRNA and protein expressions were identified at a higher level in aganglionic intestinal segments by qRT‐PCR and Western blot.