Inhibitory effect of PPARα on glioma cell proliferation is blocked by targeting regulation of miR‐19, progression of tumour is enhanced.37 p53 has also been identified to be the target gene of miR‐19 in Hela cell.40 In glioma, expression of p53 is correlated negatively with that of miR‐19.31 p53 can impose cell cycle arrest and inhibit cell growth by decreasing the expression of Cyclin E1 and CDK2.41, 42 MiR‐19 promotes glioma cell proliferation that might be through inhibition on p53. The gene discussed is CCNE1; the disease is central nervous system cancer.