p53 induces p53‐dependent apoptosis through enhanced expression of transcription targets including STAG1, PUMA and PERP.32, 33, 34 MiR‐19 expression has been identified up‐regulated in glioma as oncomiR,24 apoptosis inducing proteins such as PTEN (directly suppressed by miR‐19) and p53 (negative regulated by miR‐19) are suppressed, so miR‐19 reduces apoptosis to promote tumour cell survival. This evidence concerns the gene TP53 and central nervous system cancer.