Inhibition of miR‐19 by anti‐miR‐19 results in diminished proliferation of glioma cell in vitro.28 MiR‐19 depresses growth of glioma cells by negative regulation of PTEN, which can inhibit glioma cell proliferation by suppressing PI3k/AKT pathway.36 It also has been reported that miR‐19 promotes glioma progression by directly suppressing PPARα (the peroxisome proliferator‐activated receptor α, PPARα).37 PPAR belongs to nuclear receptor family which includes three subtypes, ie, PPARα, PPARγ and PPARδ. Here, PTEN is linked to central nervous system cancer.