FOXO1 and glioma: PPARα can inhibit glioma cell proliferation and induce cell cycle arrest by promoting nuclear translocation of FoxO1, then increases the expression of a FoxO1‐dependent cell cycle‐related protein, p27kip in glioma cells.38 The antitumour role of PPARα also can be mediated by direct and indirect antiangiogenic effect on tumour cells.39 MiR‐19 directly down‐regulates the expression of PPARα by binding to 3′‐UTR region of PPARα mRNA in gliomas.