Based on the American Society for apheresis' guidelines, PEX therapy is considered a first-line therapy (Category I) in people with clinicopathological signs, complement-mediated TMA (Factor H autoantibodies), drug-associated TMA (e.g., ticlopidine) and TTP (7, 8, 10, 11). This evidence concerns the gene CFH and thrombotic thrombocytopenic purpura.