Genes harboring significant mutations included BRAF, CDKN2A, NRAS, PTEN, and TP53 in cutaneous melanoma, BRAF, NRAS, NF1, and KIT in acral melanoma (hands and feet), and SF3B1 in mucosal melanoma (internal body surfaces) (15–17). The gene discussed is BRAF; the disease is acral lentiginous melanoma.