Although these studies consistently suggest that LSD1 expression is important for AML development and/or maintenance, particularly in the presence of MLL mutations, transgenic mice overexpressing LSD1 in hematopoietic stem and progenitor cells showed increased stem cells self-renewal through upregulation of HOXA, but did not develop overt leukemia (63). This evidence concerns the gene KMT2A and acute myeloid leukemia.