One important rationale to develop LSD1 inhibitors for AML treatment came from preclinical studies, where LSD1 inhibition was coupled with all-trans retinoic acid (ATRA) with the aim of de-repressing myeloid differentiation genes and sensitizing non-APL AMLs to ATRA-induced differentiation, thus expanding the extraordinary benefit of differentiation therapy beyond the boundaries of APL (17). Here, KDM1A is linked to acute promyelocytic leukemia.