As a consequence, T3775440-mediated dissociation of the LSD1–GFI1B complex induces transcriptional derepression of GFI1B target genes leading to cell transdifferentiation and growth inhibition and/or apoptosis in GFI1B-expressing acute erythroid leukemia and acute megakaryoblastic leukemia cell lines (68), thus suggesting its use for the treatment of M6 and M7 AML patients. Here, GFI1B is linked to acute erythroid leukemia.