GFI1B and acute megakaryoblastic leukemia: As a consequence, T3775440-mediated dissociation of the LSD1–GFI1B complex induces transcriptional derepression of GFI1B target genes leading to cell transdifferentiation and growth inhibition and/or apoptosis in GFI1B-expressing acute erythroid leukemia and acute megakaryoblastic leukemia cell lines (68), thus suggesting its use for the treatment of M6 and M7 AML patients.