AXIN1 is the second most frequently mutated gene in the Wnt pathway (occurring in 2–20% of HCC cases) (Satoh et al., 2000; Guichard et al., 2012; Kan et al., 2013; Ahn et al., 2014; Totoki et al., 2014; Schulze et al., 2015; Kawai-Kitahata et al., 2016). This evidence concerns the gene AXIN1 and hepatocellular carcinoma.