AXIN1 and hepatocellular carcinoma: Adenovirus mediated gene transfer of wild-type AXIN1 induced apoptosis in hepatocellular cancer cells that had accumulated β-catenin as a consequence of mutations in APC, CTNNB1, or AXIN1 genes, suggesting that AXIN1 may be an effective therapeutic molecule for suppressing HCC growth (Satoh et al., 2000).