On the other hand, a number of mutations appear to be mutually exclusive and rarely appear together in the same tumor, such as CTNNB1 mutations with TP53 mutations (Guichard et al., 2012; Ahn et al., 2014) and AXIN1 mutations with CTNNB1 mutations (Satoh et al., 2000). Here, CTNNB1 is linked to neoplasm.