Adenovirus mediated gene transfer of wild-type AXIN1 induced apoptosis in hepatocellular cancer cells that had accumulated β-catenin as a consequence of mutations in APC, CTNNB1, or AXIN1 genes, suggesting that AXIN1 may be an effective therapeutic molecule for suppressing HCC growth (Satoh et al., 2000). Here, APC is linked to hepatocellular carcinoma.