TP53 and hepatocellular carcinoma: TP53 mutations occurred in approximately 10% to 50% of HCC cases (Li et al., 2011; Woo et al., 2011; Fujimoto et al., 2012; Guichard et al., 2012; Huang et al., 2012; Cleary et al., 2013; Kan et al., 2013; Nault et al., 2013; Ahn et al., 2014; Meng et al., 2014; Totoki et al., 2014; Schulze et al., 2015; Kawai-Kitahata et al., 2016; Yao S. et al., 2016).