The percentage of CXCR4+ NK cells [14.36% (7.49–54.45) in SSc versus 60.9% (48.79–69.44) in SSc; p = 0.009; Figure 4C], and CXCR4 expression level at the surface of NK cells [0.23 (0.1–1.1) in SSc versus 1.14 (1–1.4); p = 0.0032; Figure 4D] were significantly lower in patients than in controls. This evidence concerns the gene CXCR4 and systemic sclerosis.