ABCA1 and systemic lupus erythematosus: Deficiency of the NOD-like receptor family pyrin domain containing 3 (NLRP3) partly reversed some of the lupus-like features, as well as the increase in IL-1β and Th1 expansion indicating that this pathway contributes to aspects of the autoimmunity phenotype in DC-Abca1/g1 deficiency(14).