Regulates interaction between activated T cells and B cells which is crucial to B cell proliferation and antibody production (78); mediates antigen presentation and augments antibody responses (79); CD1d knockout in mice impairs resistance to Borrelia burgdorferi infection due to impaired antibody production (80); CD1d upregulation on Breg cells is induced by chronic intestinal inflammatory conditions (81). The gene discussed is CD1D; the disease is Lyme disease.