Other potential DNA sensors include DNA-dependent protein kinase (DNA-PK), IFN-γ-inducible protein 16 (IFI16, also known as AIM2, absent in melanoma 2), DNA-dependent activator of IFN-regulatory factors (DAI), and DExD/H-box helicase (DDX) 41, etc. (Mansur et al., 2014). This evidence concerns the gene ZBP1 and melanoma.