In newly diagnosed type 2 diabetic patients, Hu et al found that serum ANGPTL8 positively correlated with fasting glucose and 2-h post-OGTT glucose (10), moreover, the results of their study and another research both proved that circulating ANGPTL8 levels were positively associated with indexes of insulin resistance in newly diagnosed type 2 diabetic patients (10, 11). Here, ANGPTL8 is linked to Insulin resistance.