In subgroups of type 2 diabetic patients categorized by albuminuria, serum ANGPTL8 levels were positively correlated with TG and ACR and negatively correlated with eGFR in the subgroups of type 2 diabetic patients with A2 and A3, significant correlation was not observed between ANGPTL8 and TG, ACR or eGFR in the subgroups of type 2 diabetic patients with A1. This evidence concerns the gene ANGPTL8 and type 2 diabetes mellitus.