In our study, logistic regression analysis revealed that longer duration of diabetes, elevated levels of TG and ANGPTL8 were all significantly related to an increased risk of albuminuria in type 2 diabetes, in addition, ANGPTL8 had the highest OR for albuminuria risk among these parameters above, suggesting ANGPTL8 to be a novel biomarker for diabetic kidney disease in type 2 diabetes. Here, ANGPTL8 is linked to diabetic kidney disease.