As presented in Table 4, multivariate binary logistic regression without adjustment demonstrated that serum ANGPTL8 levels were significantly related to A2 [odds ratio (OR) 2.49 (95% CI 1.17–5.32), P = 0.019] and A3 [4.51 (95% CI 2.01–10.12), P < 0.001] in type 2 diabetes. The gene discussed is ANGPTL8; the disease is type 2 diabetes mellitus.