A study conducted in human neuronal stem cells proposed that activation of AMPK via metformin is neuroprotective against Aβ (176) and other in vitro studies showed that metformin is able to reduce tau phosphorylation via mTOR/PP2A (Protein phosphates 2A) signaling (54) and that it can reduce molecular pathologies associated with AD (177). Here, MAPT is linked to Alzheimer disease.