NR0B1 and chronic primary adrenal insufficiency: The activation of the FXRα receptor in Leydig cells induces transcription of the gene encoding the orphan nuclear receptors SHP (Small Heterodimer Partner, Nr0b2) and DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1, Nr0b1), two orphan nuclear receptors, which are negative regulators of steroidogenic Leydig cells activity.