Immunohistochemical analyses of human AD brain tissues reported loss of astrocytic EAAT receptor expression in close proximity to amyloid plaques (Jacob et al., 2007) with a trend for decreased immunoreactivity of EAAT2 with increasing Braak stage, which was inversely correlated with increasing GFAP immunoreactivity in astrocytes with disease duration (Simpson et al., 2010). Here, SLC1A2 is linked to Alzheimer disease.