Given the low level of detection of pfkfb3 (Figure 6; Tasic et al., 2016), it is unlikely that 3xTg-AD pyramidal cells upregulate glycolysis via fructose 2,6-bisphosphate production (Almeida et al., 2004; Herrero-Mendez et al., 2009). Here, PFKFB3 is linked to Alzheimer disease.