However, in future studies with novel constitutive and conditional Shank2 mouse lines, the expression of the residual truncated isoforms should be analyzed in more details, and the full battery of behavioral analysis covering ASD, SCZ, mania and Attention Deficit Hyperactivity Disorder (ADHD) has to be applied, since the existing Shank2 mouse models showed very distinct, unpredictable phenotype despite very similar genetic manipulations. The gene discussed is SHANK2; the disease is attention deficit-hyperactivity disorder.