The association between inflammation and major depression has been supported by the well-known clinical observation that pro-inflammatory cytokines such as interferon (IFN)-α, which is used to treat hepatitis C, renal cancer, and multiple myeloma, and interleukin (IL)-2, which is used to treat renal cancer and angiosarcoma, frequently induce depressive symptoms as side effects (Hashioka et al., 2009). The gene discussed is IL2; the disease is renal carcinoma.