KDM3A, C, KDM4A-D, KDM5A-C, KDM6B, C, KDM8 (this study)) have been found to be overexpessed in PCa, and several of them correlate with poor prognosis, indicating a critical role of histone demethylation in tumorigenesis [9]. The gene discussed is KDM8; the disease is posterior cortical atrophy.