PMP22 and Charcot-Marie-Tooth disease type 1A: In fact, almost all lipid-associated transcripts follow a similar expression pattern with lipid genes failing to be upregulated in Pmp22 transgenic Schwann cells during myelination (Pattern 1, to a lesser extent Pattern 3, Fig. 1a), indicating that Schwann cells display an impaired ability to mount a lipid biosynthetic transcriptional program in CMT1A disease.