In addition, Rheb is beneficial for the attenuation of neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, and Huntington disease by secreting brain-derived growth factors (BDGF) and glial-derived neurotrophic factors, suggesting that Rheb plays an important role in the central nervous system. Here, GDNF is linked to early-onset autosomal dominant Alzheimer disease.