SOX2 and cancer: Another potential agent, honokiol, a biologically active biphenolic compound isolated from Magnolia officinalis, has been shown to inhibit cancer cell proliferation, survival, cancer stemness, migration and invasion, through the downregulation of EZH2 expression levels, along with reductions in the expression of matrix metalloproteinase 9, CD44, SOX2 and the induction of tumor suppressor miR-143 in bladder cancer [52].