Future studies are needed to determine the interactions of E2F3 with other genes in the 6p22 amplicon such as SOX4. In addition, other potential oncogenes, such as CCND1 not in the 6p22 amplicon but yet frequently altered in bladder cancer and dependent on E2F3 could be secondarily impacted. The gene discussed is E2F3; the disease is urinary bladder carcinoma.