Sato T et al. reported that the incidence of fatal acute exacerbation occurred after resection of lung cancer in patients with interstitial lung disease at a rate of 4.0%, and the surgical procedures, male sex, history of exacerbation, preoperative regular use of steroid use, serum sialylated carbohydrate antigen KL-6 levels, usual interstitial pneumonia appearance on computed tomography scan, and reduced percentage of predicted vital capacity were identified as risk factors of acute exacerbation [19]. The gene discussed is MUC1; the disease is lung carcinoma.