While HSP90 inhibitors have shown remarkable efficacy in preclinical in vitro and in vivo studies in cancers such as mutant EGFR lung cancer [50–54], clinical trials of these inhibitors in NSCLC have unfortunately been disappointing with poor response rates and high toxicities in the first-line and acquired KI resistance settings [55–57]. Here, EGFR is linked to non-small cell lung carcinoma.