SACS and autosomal recessive spastic ataxia: This resulted in a list of 287 proteins (Table S3), of which the top two hits were Huntingtin (Htt) and sacsin, proteins that when mutated lead to the neurodegenerative diseases Huntington's disease (HD) and autosomal-recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), respectively (Saudou and Humbert, 2016).