Activity of p38 MAPK is also under investigation in Huntington’s disease, where polyglutamine-expanded huntingtin activates p38 signaling in neurons and the overexpression of Mitogen-activated Protein Kinase/Dual-specificity Phosphatase 1 (MKP-1) prevents this activation, possibly having an impact on neuroprotection [64]. The gene discussed is DUSP1; the disease is Huntington disease.