In addition, surprisingly UL41 null virus infection could significantly downregulate the expression of β-actin (Fig. 8a) and GAPDH (Fig. 8b) at the timepoint of 3 h post infection, and this downregulation was more significant than that caused by JS-2012 and revertant virus; The CHX treatment on virus-infected cells could significantly reduce the viral UL41 gene expression by more than 10 folds (Fig. 8c), but has no significant effect on the downregulation of β-actin (Fig. 8a) and GAPDH (Fig. 8b) expression caused by virus infection. The gene discussed is ACTB; the disease is viral infectious disease.