This difference is expected to have clinical benefits as a study by Kolsgaard et al. (2011) showed that even a modest reduction in BMI z-score (≥0.00 - < 0.1) was associated with significant improvement in several cardiovascular risk factors i.e. improved insulin and insulin resistance, total cholesterol, LDL cholesterol and total/HDL cholesterol ratio [38]. The gene discussed is INS; the disease is Insulin resistance.