A follow-up study by the same authors using a cockroach antigen (CRA) sensitization and challenge model of murine asthma recapitulated the findings of the OVA-challenged mice and demonstrated early induction of HAS1 expression that subsided within the first 24 h of the challenge; however, sustained enhanced expression of HAS2 was apparent within the first 6 h following the CRA challenge [4]. The gene discussed is HAS1; the disease is asthma.