Although Tgfb1-knockout mice develop fatal systemic autoimmune inflammation in heart, lungs, pancreas, colon and salivary glands [6,7], the immunological abnormalities in Tgfb3-knockout mice have not been reported due to death shortly after birth due to cleft palate formation and impaired lung development in Tgfb3-knockout mice [91,92]. Here, TGFB3 is linked to inflammatory response.