BCR and chronic myelogenous leukemia, BCR-ABL1 positive: EVs derived from chronic myeloid leukemia (CML) cells transfer DNA encoding the breakpoint cluster region/Abelson murine leukemia viral oncogene homolog (BCR/ABL) fusion oncogene to the neutrophils of Sprague-Dawley rats and non-obese diabetic/severe combined immunodeficient (NOD/SCID) mice in vivo resulting in increased BCR/ABL mRNA and protein in the recipient murine cells and the eventual onset of CML-like characteristics [96].