ANXA2 and neoplasm: Additional examples of RBPs with known oncogenic or tumor suppressive functions that have been linked to EV miRNA sorting include Annexin A2 (ANXA2) [29], Kirsten rat sarcoma (KRAS) [18], Y-box binding protein 1 (YB-1) [22,30], MEX3C [31], and Argonaute 2 (AGO2) [32,33,34].