However, it remains well established that HO-1 is overexpressed in the brains of patients with AD, mainly in the hippocampus and cerebral cortex, and co-localizes to neurons, neurofibrillary tangles, GFAP-positive astrocytes, choroid plexus epithelial cells, ependyma, corpora amylacea and senile plaques [107,114]. Here, HMOX1 is linked to Alzheimer disease.