Although there is a report that POU5F1B expression is positively correlated with the parent gene POU5F1 in prostate cancer [44], POU5F1B promotes angiogenesis and cell proliferation and inhibits apoptosis in gastric cancer [43], suggesting that POU5F1B-induced tumorigenesis may not be through regulation of its parent gene, instead directly or indirectly regulate genes related to angiogenesis or cell proliferation. This evidence concerns the gene POU5F1B and Familial prostate cancer.