NOS3 and myocardial ischemia: It is important to point out that upon subgroup analyses, 10 countries (Ukraine, the United Kingdom, Brazil, Chile, Japan, South Korea, India, Iran, Egypt and Morocco) demonstrated an average RR greater than 2, which presented the NOS3 894 TT polymorphism genotype as a potentially causal factor of IHD as a biological marker based on the criteria for strong evidence used in international consensus panels [59,60].