FOXO3 and Alzheimer disease: Enhancement of survival proteins p-IGF1R, p-PI3K p-AKT, Bcl-XL, Bcl2 and longevity SIRT1 signaling proteins, p-AMPK-α, SIRT1, PGC1-α, p-FOXO3 were observed in the MLE, GEE and CFE treatment and even more strongly enhanced in the MLE and GEE treatment (p < 0.05) compared with the AD group (Figure 1).