Moreover the reduction of Caspase-8 was more significant in the group of MLE treated mice (p < 0.05) compared with the AD group, but Fas receptor, FADD and Caspase-3 were strongly reduced in the group of AD + MLE, AD + GEE and AD + CFE mice (p < 0.05) compared with the AD group; moreover the reduction of BAK and C-Caspase-9 was more significant in the group of AD+MLE (p < 0.05) compared with the AD group, but the reduction of C-Caspase-3 and Cytochrome-c was more significant in the group of AD + GEE (Table 2). Here, CASP8 is linked to Alzheimer disease.