To investigate whether Meretrix lusoria, Geloina eros and Corbicula fluminea could enhance the activation of the survival pathway in AD mice, the representative protein products of p-AKT, p-IGF1R, p-PI3K, Bcl-XL, and Bcl2 were extracted from the left ventricles of excised hearts in control, AD, AD + MLE, AD + GEE and AD + CFE mice were measured by Western blotting analysis. The gene discussed is IGF1R; the disease is Alzheimer disease.