To investigate whether Meretrix lusoria, Geloina eros and Corbicula fluminea could inhibit the death receptor-dependent apoptotic pathway in AD mice, the representative protein products of Fas receptor, FADD, Caspase-8, BAK, C-Caspase-9 and Caspase-3 extracted from the left ventricles of excised hearts in control mice, AD mice, AD + MLE mice, AD + GEE mice and AD + CFE mice were measured by Western blotting analysis. The gene discussed is CASP8; the disease is Alzheimer disease.