To investigate whether Meretrix lusoria, Geloina eros and Corbicula fluminea could activate SIRT1 pathway in AD mice, the representative protein products of p-AMPK-α, SIRT1, PGC1-α, and p-FOXO3 were extracted from the left ventricles of excised hearts in control, AD, AD + MLE, AD + GEE and AD + CFE mice were measured by Western blotting analysis. This evidence concerns the gene SIRT1 and Alzheimer disease.