The data in Figure 2, obtained with human ovarian cancer (A2780) cells, indicate that cisplatin resistance correlates not only with a reduced expression of CTR1 and increased expression of ATPA and ATPB, which in itself will reduce Pt accumulation, but also a significant reduction in LRRC8A protein expression (Figure 2A). This evidence concerns the gene LRRC8A and ovarian carcinoma.