NR3C1 and Alzheimer disease: The hippocampus, which is affected in the early stages of classical or amnestic AD, has, as already highlighted, a high concentration of GCr; and therefore, plays an important role in cortisol regulation, inhibiting the hypothalamic-pituitary-adrenal axis after stressor-induced cortisol elevations, allowing cortisol increases after psychosocial stress, and controlling the cortisol awakening response [51].