Our systematic review confirmed the previously reported association of CIMP with high MSI, BRAF mutations, lack of KRAS mutations, poor differentiation, mucinous histologic characteristics, right-sided tumor location, female sex, and older age, In addition to this, to the best of our knowledge, we are the first to confirm association of CIMP with T staging (T3/T4), TILS, Crohn-like infiltrates, LVI, wild-type TP53, PIK3CA mutations, and high levels of Fusobacterium nucleatum, and an inverse association with black race using meta-analysis. The gene discussed is PIK3CA; the disease is neoplasm.