BRAF and neoplasm: CIMP is a distinct phenotype characterized by high promoter methylation of several genes including MINT clones, p16, THBS, and MLH1 as first shown by Toyata et al. in CRC tissues and is characterized by key clinical, pathologic, and molecular characteristics, including female sex, old age, high MSI, BRAF mutations, and right-sided tumor location [7], [8].