Researchers set up a mouse model of POF using 4-vinylcyclohexene diepoxide (VCD) and explored its effects on a variety of factors (e.g., phosphorylation in response to Rictor overexpression, the phosphorylation of Akt and the inhibition of Foxo3a expression) and on Rictor and its downstream mTORC2 signalling molecules (e.g., the Rictor/mTORC2/Akt/Foxo3a signalling axis) [22–25]. The gene discussed is FOXO3; the disease is premature menopause.