TBX18 protein with loss of the C-terminal region and unchanged eh1-motif from a CAKUT patient exhibited reduced repressive activity in vitro [24] indicating that additional corepressors exist both in 293 cells as well as in vivo and that they may bind to the large C-terminal region of TBX18 to augment its repressive activity. The gene discussed is TBX18; the disease is congenital anomaly of kidney and urinary tract.