BRCA2 and ovarian carcinoma: As an example, we discuss the 10 genes relevant to three autosomal dominant high-penetrance conditions that seem immediately appropriate for implementation science research: hereditary breast and ovarian cancer risk associated with BRCA 1 and BRCA2 mutations, Lynch syndrome (colorectal, endometrial, and other cancers) associated with mutations in mismatch repair genes, and familial hypercholesterolemia (FH) associated with dysfunctional cholesterol processing.