As an example, we discuss the 10 genes relevant to three autosomal dominant high-penetrance conditions that seem immediately appropriate for implementation science research: hereditary breast and ovarian cancer risk associated with BRCA 1 and BRCA2 mutations, Lynch syndrome (colorectal, endometrial, and other cancers) associated with mutations in mismatch repair genes, and familial hypercholesterolemia (FH) associated with dysfunctional cholesterol processing. The gene discussed is BRCA2; the disease is cancer.