The genotype distribution of the TGFB1 -509C/T polymorphism between cases of 1st and 2nd stages of CRC was very similar (χ2 = 0.278; p = 0.87) as well as between 3rd and 4th stages (χ2 = 0.153; p = 0.926). The gene discussed is TGFB1; the disease is colorectal carcinoma.