The correlation of immunohistochemical expression with the clinicopathological parameters associated with CRC revealed that high TGF-β expression and low TGF-βR1, TGF-βR2, Smad4, pSmad2/3, and E-cadherin expression were correlated with the tumor–node–metastasis (TNM) stage of the disease [34]. The gene discussed is SMAD4; the disease is neoplasm.