Wilhelmsen M et al found that a combination of all 8 serological protein biomarkers, including alpha fetoprotein (AFP), CA19-9, CEA, high-sensitivity C-reaction protein (hs-CRP), CyFra21-1, ferritin, galectin-3 and tissue inhibitor of metalloproteinases-1 (TIMP-1), provided a significant improvement for the identification of subjects with a high risk of CRC [21]. Here, TIMP1 is linked to colorectal carcinoma.