Interestingly, deafness mutations in LHFPL5 do not affect the interaction of PCDH15 and LHFPL5 (Xiong et al., 2012) and in our structure do not localize to interaction sites of PCDH15 and LHFPL5, suggesting that LHFPL5 interacts with additional components of the mechanotransduction complex (Beurg et al., 2015; Xiong et al., 2012) (Figure 6). This evidence concerns the gene PCDH15 and deafness.